ISSN 1016-5169 | E-ISSN 1308-4488
Archives of the Turkish Society of Cardiology
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The effect of carvedilol on big endothelin, atrial and brain natriuretic peptide levels in patients with congestive heart failure [Turk Kardiyol Dern Ars]
Turk Kardiyol Dern Ars. 2007; 35(7): 412-416

The effect of carvedilol on big endothelin, atrial and brain natriuretic peptide levels in patients with congestive heart failure

Serdar Sevimli1, Mustafa Yılmaz1, Ahmet Kızıltunç2, Fuat Gündoğdu1, Şakir Arslan1, Hakan Hamit Alp2, Enbiya Aksakal1, Hakan Taş1, Hanefi Yekta Gürlertop1, Hüseyin Şenocak1
1Department Of Cardiology, Ataturk University, Medical School Hospital, Erzurum,turkey
2Department Of Biochemistry,ataturk University, Medical School Hospital,erzurum-turkey


OBJECTIVES
We investigated the changes in plasma big endothelin (big ET), atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) levels during carvedilol therapy in patients with congestive heart failure (CHF).

STUDY DESIGN
The study included 20 patients (6 females, 14 males; mean age 57±11 years) with symptomatic CHF. All the patients had sinus rhythm and resting ejection fraction ≤40%. Carvedilol therapy was initiated with a minimum dose (2 x 3.125 mg), which was increased biweekly to reach the maximum tolerable dose. Blood samples were obtained and transthoracic echocardiography was performed before and after three months of a mean carvedilol dose of 42.5±13.6 mg. Big ET, ANP, and BNP levels were assessed and correlations were sought with left ventricular functions and the NYHA (New York Heart Association) functional class.

RESULTS
After three months, significant decreases were detected in heart rate (p<0.001), systolic blood pressure (p<0.05), and left atrial diameter (p<0.001), accompanied by a significant increase in left ventricular ejection fraction (EF) (p<0.001), and a remarkable improvement in NYHA class (p<0.05). Significant decreases were observed in ANP, BNP, and big ET levels with carvedilol treatment (p<0.001). Big ET, ANP, and BNP levels showed significant correlations with left ventricular dimensions and systolic functions, and NYHA functional class. Among these, the best correlation was with LVEF (r= -0.498, p=0.001; r= -0.642, p<0.001; r= -0.656, p<0.001; respectively).

CONCLUSION
Carvedilol therapy is associated with decreased BNP, ANP, and big ET levels and with improvements in NYHA functional class and left ventricular systolic functions in patients with CHF.

Keywords: Atrial natriuretic factor, biological markers; carbazoles/therapeutic use; endothelin-1; heart failure, congestive/drug therapy; natriuretic peptide, brain

How to cite this article
Serdar Sevimli, Mustafa Yılmaz, Ahmet Kızıltunç, Fuat Gündoğdu, Şakir Arslan, Hakan Hamit Alp, Enbiya Aksakal, Hakan Taş, Hanefi Yekta Gürlertop, Hüseyin Şenocak. The effect of carvedilol on big endothelin, atrial and brain natriuretic peptide levels in patients with congestive heart failure. Turk Kardiyol Dern Ars. 2007; 35(7): 412-416

Corresponding Author: Serdar Sevimli, Türkiye
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

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